IGHV2OR16-5

Across TCGA patient cohorts, IGHV2OR16-5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,234 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV2OR16-5-associated GO terms across cancer lineages are Antigen receptor-mediated signaling pathway, Immunoglobulin production, and Regulation of cellular extravasation. Each is linked with IGHV2OR16-5 in more than 23 cancer types. Because this analysis shows association rather than direction, both IGHV2OR16-5-to-partner and partner-to-IGHV2OR16-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen receptor-mediated signaling pathway grouped by IGHV2OR16-5-low versus IGHV2OR16-5-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV2OR16-5→partner) and Y-score (partner→IGHV2OR16-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Antigen receptor-mediated signaling pathway →	+0.053	+0.214	<.001	<.001	3	24
ESCA	Immunoglobulin production →	+0.081	+0.341	<.001	<.001	3	23
PAAD	Regulation of cellular extravasation →	+0.049	+0.235	<.001	<.001	3	23
PAAD	B cell receptor signaling pathway →	+0.074	+0.234	<.001	<.001	3	23
ESCA	Positive regulation of B cell activation →	+0.051	+0.314	<.001	<.001	3	23
ESCA	Regulation of leukocyte apoptotic process →	+0.046	+0.285	<.001	.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,234 associations by consensus.

Antigen receptor-mediated signaling pathway by IGHV2OR16-5 expression — PAAD

Explore this box plot interactively →