IGHV2OR16-5

Across TCGA pan-cancer cohorts, IGHV2OR16-5 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGHV2OR16-5 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGHV2OR16-5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV2OR16-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

KICH, HNSC, and ACC are the cancer types where IGHV2OR16-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.053	0.918	<.001	144	view →
HNSC	DFS	Tertile	All	0.826	0.654	<.001	129	view →
ACC	DFS	Tertile	All	0.046	0.753	<.001	108	view →
BRCA	OS	Quartile	All	0.981	0.955	.004	62	view →
LUAD	DFS	Median	II,III,IV	0.677	0.468	.003	44	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
CESC	DFS	Tertile	All	0.845	0.697	.007	34	view →
OV	DFS	Tertile	IV	0.334	0.493	.029	24	view →
KIRP	DFS	Tertile	All	0.537	0.799	.042	15	view →
SKCM	DFS	Quartile	All	0.707	0.592	.005	14	view →
STAD	OS	Median	IV	0.642	0.203	.006	9	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGHV2OR16-5–KICH (DFS)

Open the KICH breakdown →