IGHV2-70

Across TCGA pan-cancer cohorts, IGHV2-70 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGHV2-70 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV2-70 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV2-70 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where IGHV2-70 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.634	0.858	.013	8	view →
CCRCC	DFS	Median	II,III,IV	0.090	1.000	.020	6	view →
LUAD	OS	Median	All	0.902	0.971	.019	4	view →
PDAC	DFS	Median	III,IV	0.393	0.855	.034	3	view →
LSCC	DFS	Median	All	0.860	0.724	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGHV2-70–HNSC (OS)

Open the HNSC breakdown →