IGHV1OR21-1

Across TCGA pan-cancer cohorts, IGHV1OR21-1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGHV1OR21-1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGHV1OR21-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV1OR21-1 expression acts as an unfavorable survival marker.

COAD, ESCA, and SARC are the cancer types where IGHV1OR21-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.125	0.799	<.001	29	view →
ESCA	OS	Median	II,III,IV	0.117	0.703	<.001	24	view →
SARC	DFS	Median	All	0.140	0.615	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGHV1OR21-1–COAD (OS)

Open the COAD breakdown →