IGHV1OR16-2

Across TCGA pan-cancer cohorts, IGHV1OR16-2 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGHV1OR16-2 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGHV1OR16-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV1OR16-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UVM, CHOL, and HNSC are the cancer types where IGHV1OR16-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
CHOL	OS	Tertile	All	0.245	0.754	<.001	45	view →
HNSC	DFS	Tertile	III,IV	0.721	0.541	.010	39	view →
LUAD	DFS	Quartile	II,III,IV	0.772	0.366	.001	35	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	18	view →
COAD	OS	Tertile	All	0.721	0.881	.013	18	view →
BLCA	DFS	Tertile	III,IV	0.584	0.288	.025	12	view →
PCPG	DFS	Tertile	All	0.688	0.920	.004	9	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	9	view →
SKCM	OS	Tertile	All	0.506	0.313	.015	6	view →
READ	DFS	Tertile	IV	1.000	0.493	.039	6	view →
LIHC	OS	Tertile	All	1.000	0.766	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGHV1OR16-2–UVM (OS)

Open the UVM breakdown →