IGHV1OR15-1

Across TCGA pan-cancer cohorts, IGHV1OR15-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGHV1OR15-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1OR15-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1OR15-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, MESO, and COAD are the cancer types where IGHV1OR15-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.775	0.650	<.001	144	view →
MESO	OS	Tertile	III,IV	0.796	0.482	.001	54	view →
COAD	DFS	Tertile	II,III,IV	0.896	0.625	.002	42	view →
UCEC	OS	Tertile	IV	0.066	0.755	<.001	36	view →
LUAD	OS	Median	II,III,IV	0.835	0.671	.003	28	view →
SKCM	DFS	Quartile	All	0.698	0.594	.011	24	view →
PAAD	DFS	Median	II,III,IV	0.420	0.221	<.001	24	view →
KIRC	DFS	Tertile	IV	0.143	0.396	.012	18	view →
OV	OS	Tertile	III,IV	0.774	0.853	.025	18	view →
ESCA	DFS	Quartile	II,III,IV	0.459	0.218	.008	15	view →
KIRP	DFS	Tertile	All	0.504	0.819	.030	12	view →
BLCA	DFS	Tertile	All	0.523	0.238	.042	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGHV1OR15-1–HNSC (DFS)

Open the HNSC breakdown →