IGHV1OR15-1

Across TCGA pan-cancer cohorts, IGHV1OR15-1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHV1OR15-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1OR15-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1OR15-1 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGHV1OR15-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1OR15-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.585	<.001	9	view →
LUAD	Male	All	+0.490	<.001	7	view →
LIHC	All	II,III,IV	−0.041	.028	3	view →
KIRC	All	All	+0.052	.010	2	view →
BLCA	Male	IV	+0.285	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGHV1OR15-1–COAD

Open the COAD breakdown →