IGHV1-69D

Across TCGA pan-cancer cohorts, IGHV1-69D mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGHV1-69D data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV1-69D mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV1-69D expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where IGHV1-69D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.839	1.000	.007	19	view →
PDAC	OS	Tertile	All	0.750	0.399	.020	11	view →
LSCC	DFS	Quartile	II,III,IV	0.791	1.000	.014	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IGHV1-69D–LUAD (OS)

Open the LUAD breakdown →