IGHV1-67

Across TCGA pan-cancer cohorts, IGHV1-67 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHV1-67 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-67 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-67 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGHV1-67 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.409	0.260	<.001	144	view →
SKCM	OS	Tertile	All	0.430	0.264	<.001	111	view →
UCEC	DFS	Tertile	III,IV	0.719	0.450	.003	64	view →
BRCA	OS	Tertile	All	0.977	0.942	.002	57	view →
LUAD	DFS	Quartile	III,IV	0.847	0.279	.001	40	view →
OV	DFS	Median	II,III,IV	0.582	0.500	.021	30	view →
ACC	DFS	Tertile	II,III,IV	0.137	0.590	.041	27	view →
CESC	OS	Median	All	0.851	0.738	.011	26	view →
UCS	DFS	Tertile	All	0.707	0.438	.019	20	view →
READ	DFS	Median	IV	0.760	0.382	.012	12	view →
TGCT	DFS	Median	All	0.910	0.755	.007	10	view →
GBM	OS	Tertile	All	0.192	0.433	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHV1-67–HNSC (DFS)

Open the HNSC breakdown →