IGHV1-67

Across TCGA pan-cancer cohorts, IGHV1-67 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGHV1-67’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV1-67 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV1-67 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV1-67 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1-67 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.333	<.001	9	view →
LUAD	All	III,IV	+1.888	<.001	9	view →
BRCA	Female	II,III,IV	−0.475	.009	6	view →
KIRC	Male	All	+0.695	<.001	4	view →
STAD	All	IV	−3.860	.007	2	view →
READ	Female	All	−2.114	.003	2	view →
HNSC	All	III,IV	+0.781	.021	2	view →
LUSC	All	All	+0.780	.015	2	view →
LIHC	Male	All	−0.427	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGHV1-67–COAD

Open the COAD breakdown →