Across TCGA pan-cancer cohorts, IGHV1-46 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHV1-46’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IGHV1-46 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGHV1-46 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where IGHV1-46 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV1-46 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.710	<.001	9	view →
LSCC	Male	All	−0.430	<.001	6	view →
LUAD	All	All	−0.279	<.001	5	view →
PDAC	All	All	+0.365	.022	2	view →
CCRCC	All	All	+0.250	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: IGHV1-46 RNA expression & survival · all IGHV1-46 data types