Across TCGA pan-cancer cohorts, IGHV1-46 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV1-46 data layer compared with 4 for mutation status and 5 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-46 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV1-46 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.
HNSC, BRCA, and SKCM are the cancer types where IGHV1-46 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.