Across TCGA patient cohorts, IGHV1-46 protein abundance is significantly associated with the RNA expression of many other genes, with 8,459 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV1-46-associated genes across cancer lineages are IL21R, FCGR2B, and IGKV1-5. Each is linked with IGHV1-46 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHV1-46-to-partner and partner-to-IGHV1-46 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-46→partner) and Y-score (partner→IGHV1-46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL21R →	+1.006	+0.779	<.001	<.001	3	6
GBM	FCGR2B →	+0.875	+0.621	.001	<.001	3	6
BRCA	IGKV1-5 →	+1.996	+0.541	<.001	<.001	3	6
CCRCC	LILRB5 →	+1.196	+0.635	<.001	<.001	3	5
HNSC	POU2AF1 →	+1.223	+0.588	<.001	<.001	3	5
HNSC	BIN2 →	+0.925	+0.772	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,459 associations by consensus.

Exploration

IGHV1-46 survival (RNA) · tumor vs normal (RNA) · all IGHV1-46 data types