Across TCGA patient cohorts, IGHV1-46 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. ESCA shows the largest number of these associations.

The most reproducible IGHV1-46-associated genes across cancer lineages are CD8+ T-cells, Megakaryocytes, and GMP. Each is linked with IGHV1-46 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV1-46-to-partner and partner-to-IGHV1-46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-46→partner) and Y-score (partner→IGHV1-46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD8+ T-cells →	+0.026	+3.430	.004	.029	3	2
HNSC	Megakaryocytes →	+0.037	+3.307	<.001	.025	3	1
LUSC	GMP →	+0.080	+3.264	<.001	.046	3	1
ESCA	CD8+ Tem →	+0.018	+5.285	<.001	.049	3	1
ESCA	NK cells →	+0.002	+5.709	.002	.037	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

IGHV1-46 survival (RNA) · tumor vs normal (RNA) · all IGHV1-46 data types