IGHV1-3

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV1-3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,985 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV1-3-associated proteins across cancer lineages are RCSD1, WAS, and HCLS1. Each is linked with IGHV1-3 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV1-3-to-partner and partner-to-IGHV1-3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-3→partner) and Y-score (partner→IGHV1-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVRCSD1 →+0.594+3.111<.001<.001310
LSCCWAS →+0.524+2.553<.001<.001310
OVHCLS1 →+0.731+3.505<.001<.001310
LSCCLSP1 →+0.578+3.039<.001<.001310
OVMZB1 →+1.224+3.577<.001<.001310
OVSASH3 →+0.591+3.886<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 12,985 associations by consensus.

Exploration