Across TCGA pan-cancer cohorts, IGHV1-18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGHV1-18 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-18 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGHV1-18 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where IGHV1-18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
LUAD	DFS	Tertile	All	0.939	0.583	.020	5	view →
UCEC	DFS	Quartile	All	0.865	1.000	.035	4	view →
CCRCC	DFS	Quartile	III,IV	0.731	0.290	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGHV1-18 tumor-vs-normal RNA expression · all IGHV1-18 data types