IGHV1-17

Across TCGA patient cohorts, IGHV1-17 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,693 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV1-17-associated proteins across cancer lineages are SEPTIN1, MZB1, and CD2. Each is linked with IGHV1-17 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHV1-17-to-partner and partner-to-IGHV1-17 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV1-17 versus SEPTIN1 in BRCA, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV1-17→partner) and Y-score (partner→IGHV1-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN1 →	+0.720	+0.669	<.001	<.001	3	8
OV	MZB1 →	+1.250	+0.395	<.001	<.001	3	8
LSCC	CD2 →	+0.593	+0.643	<.001	<.001	3	7
HNSC	IL16 →	+0.537	+0.729	<.001	<.001	3	7
BRCA	CD38 →	+0.823	+0.401	<.001	<.001	3	7
BRCA	MAP4K1 →	+0.509	+0.346	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,693 associations by consensus.

IGHV1-17 vs SEPTIN1 — BRCA

Explore this scatter interactively →