IGHV1-17

Across TCGA pan-cancer cohorts, IGHV1-17 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV1-17 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV1-17 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV1-17 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGHV1-17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.803	0.699	<.001	128	view →
SKCM	OS	Median	II,III,IV	0.392	0.239	<.001	97	view →
UCEC	OS	Quartile	II,III,IV	0.872	0.286	<.001	88	view →
BRCA	DFS	Median	All	0.964	0.933	.011	35	view →
BLCA	DFS	Quartile	All	0.556	0.208	.003	33	view →
CESC	OS	Tertile	All	0.866	0.706	.002	32	view →
CHOL	DFS	Tertile	III,IV	1.000	0.182	.034	18	view →
COAD	DFS	Tertile	All	0.796	0.661	.013	18	view →
PAAD	OS	Tertile	II,III,IV	0.670	0.394	.002	14	view →
STAD	OS	Median	IV	0.642	0.203	.006	9	view →
LUSC	OS	Median	All	0.739	0.881	.013	9	view →
PCPG	DFS	Tertile	All	0.549	0.887	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV1-17–HNSC (OS)

Open the HNSC breakdown →