Across TCGA patient cohorts, IGHM mutation is significantly associated with the RNA expression of many other genes, with 2,026 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHM-associated genes across cancer lineages are OIP5, LRR1, and ENTR1. Each is linked with IGHM in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHM-to-partner and partner-to-IGHM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHM→partner) and Y-score (partner→IGHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.578	+2.584	.001	<.001	3	4
UCEC	LRR1 →	+0.371	+2.436	.007	.001	3	4
UCEC	ENTR1 →	+0.291	+2.153	.003	<.001	3	4
COAD	TYMSOS →	+0.814	+2.906	<.001	.001	3	4
READ	RNU6-218P →	+0.655	+3.991	<.001	.001	3	3
COAD	RPARP-AS1 →	+0.367	+3.770	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,026 associations by consensus.

Exploration

IGHM survival (RNA) · tumor vs normal (RNA) · all IGHM data types