Across TCGA patient cohorts, IGHE mutation is significantly associated with the RNA expression of many other genes, with 1,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHE-associated genes across cancer lineages are RNA5SP164, RN7SL369P, and ATG10. Each is linked with IGHE in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHE-to-partner and partner-to-IGHE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHE→partner) and Y-score (partner→IGHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP164 →	+0.244	+8.471	<.001	.005	3	2
SKCM	RN7SL369P →	+0.086	+1.879	.007	.008	3	2
UCEC	ATG10 →	+0.365	+3.483	.003	.002	3	2
LUAD	FABP3P2 →	+0.149	+5.984	<.001	.002	3	2
UCEC	CYP4F36P →	+0.316	+2.368	<.001	.003	3	2
UCEC	RN7SL248P →	+0.080	+3.606	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,059 associations by consensus.

Exploration

IGHE survival (RNA) · tumor vs normal (RNA) · all IGHE data types