Across TCGA patient cohorts, IGHD4-17 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,671 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD4-17-associated proteins across cancer lineages are SEC11C, MZB1, and CD38. Each is linked with IGHD4-17 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHD4-17-to-partner and partner-to-IGHD4-17 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD4-17→partner) and Y-score (partner→IGHD4-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC11C →	+0.987	+1.258	<.001	<.001	3	5
BRCA	MZB1 →	+1.340	+1.170	<.001	<.001	3	5
BRCA	CD38 →	+1.308	+0.992	<.001	<.001	3	5
CCRCC	CD79A →	+2.425	+4.845	<.001	<.001	3	5
LSCC	SAMSN1 →	+0.513	+2.291	<.001	<.001	3	4
LSCC	SEPTIN1_S315 →	+1.032	+1.814	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,671 associations by consensus.

Exploration

IGHD4-17 survival (RNA) · tumor vs normal (RNA) · all IGHD4-17 data types