Across TCGA pan-cancer cohorts, IGHD3-9 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGHD3-9 data layer compared with 1 for mutation status.
The strongest signal is observed in uveal melanoma (UVM), where higher IGHD3-9 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHD3-9 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.
UVM, GBM, and SKCM are the cancer types where IGHD3-9 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.