Across TCGA pan-cancer cohorts, IGHD3-9 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHD3-9’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where IGHD3-9 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD3-9 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.
COAD, LUAD, and READ are the cancer types where IGHD3-9 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD3-9 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.