Across TCGA patient cohorts, IGHD3-16 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,549 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD3-16-associated proteins across cancer lineages are DOCK2, HCLS1, and IRF4. Each is linked with IGHD3-16 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHD3-16-to-partner and partner-to-IGHD3-16 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD3-16→partner) and Y-score (partner→IGHD3-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOCK2 →	+0.611	+0.925	<.001	<.001	3	6
UCEC	HCLS1 →	+0.481	+0.784	<.001	.002	3	6
LSCC	IRF4 →	+0.825	+1.637	<.001	<.001	3	6
UCEC	LIMD2 →	+0.535	+1.057	<.001	.007	3	6
BRCA	MZB1 →	+0.923	+0.770	<.001	<.001	3	6
HNSC	PTPN7 →	+0.398	+1.750	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,549 associations by consensus.

Exploration

IGHD3-16 survival (RNA) · tumor vs normal (RNA) · all IGHD3-16 data types