Across TCGA patient cohorts, IGHD3-16 RNA expression is significantly associated with the mutation status of many other genes, with 8,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHD3-16-associated genes across cancer lineages are KRAS, MUC16, and FNDC3A. Each is linked with IGHD3-16 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHD3-16-to-partner and partner-to-IGHD3-16 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD3-16→partner) and Y-score (partner→IGHD3-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	KRAS →	-1.745	-0.505	<.001	<.001	3	3
BRCA	MUC16 →	-1.712	-0.334	<.001	.002	3	3
HNSC	FNDC3A →	+3.818	+1.501	.009	<.001	3	3
COAD	EML2 →	+2.240	+1.426	.005	<.001	3	3
CESC	AFDN →	+2.389	+0.634	.003	.001	3	3
LIHC	DDX18 →	+5.447	+0.861	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,535 associations by consensus.

Exploration

IGHD3-16 survival (RNA) · tumor vs normal (RNA) · all IGHD3-16 data types