Across TCGA pan-cancer cohorts, IGHD2-8 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHD2-8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHD2-8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHD2-8 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

LUAD, KIRC, and READ are the cancer types where IGHD2-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD2-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.630	.001	4	view →
KIRC	Male	All	+0.288	.006	3	view →
READ	All	III,IV	−1.550	.013	2	view →
COAD	Female	All	−0.855	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGHD2-8 RNA expression & survival · all IGHD2-8 data types