Q-omics provides the consensus-scored IGHD2-21 profile across patient tissues and cancer cell-line models. IGHD2-21 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, IGHD2-21 is differentially expressed in 5, with the highest sampling consensus in HNSC. Additionally, IGHD2-21 RNA expression shows 7,285 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight THCA, HNSC, and LSCC as cancer lineages where IGHD2-21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IGHD2-21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IGHD2-21 survival associations across molecular data types. IGHD2-21 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IGHD2-21 RNA expression–survival associations across cancer types. High IGHD2-21 expression shows unfavorable associations in THCA, ACC, KIRC, THYM, DLBC and UCEC. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify THCA as the clearest survival context for IGHD2-21 RNA expression.
This table summarizes IGHD2-21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for IGHD2-21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IGHD2-21 shows lower tumor expression in PAAD, COAD and STAD and higher tumor expression in HNSC and LUAD. The HNSC box plot shows higher IGHD2-21 RNA expression in tumor versus normal tissue (log2 FC = +0.349, t-test p = .016).
This table shows molecular features associated with IGHD2-21 in patient tissues and cancer cell lines. In patient samples, IGHD2-21 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
