Across TCGA patient cohorts, IGHD2-2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,988 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD2-2-associated proteins across cancer lineages are RASAL3, SEPTIN1, and LPXN. Each is linked with IGHD2-2 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHD2-2-to-partner and partner-to-IGHD2-2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD2-2→partner) and Y-score (partner→IGHD2-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASAL3 →	+0.503	+1.994	<.001	<.001	3	7
BRCA	SEPTIN1 →	+0.861	+1.525	<.001	<.001	3	7
HNSC	LPXN →	+0.532	+2.098	<.001	<.001	3	7
OV	MZB1 →	+1.138	+1.210	<.001	.001	3	7
OV	ARHGAP30 →	+0.543	+1.106	.001	<.001	3	7
BRCA	PTPRC →	+0.634	+1.942	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,988 associations by consensus.

Exploration

IGHD2-2 survival (RNA) · tumor vs normal (RNA) · all IGHD2-2 data types