IGHD1-7

Across TCGA patient cohorts, IGHD1-7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,817 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHD1-7-associated GO terms across cancer lineages are B cell activation, B cell mediated immunity, and Immunoglobulin production. Each is linked with IGHD1-7 in more than 17 cancer types. Because this analysis shows association rather than direction, both IGHD1-7-to-partner and partner-to-IGHD1-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell activation grouped by IGHD1-7-low versus IGHD1-7-high in PRAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD1-7→partner) and Y-score (partner→IGHD1-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	B cell activation →	+0.085	+0.111	<.001	.001	3	18
THCA	B cell mediated immunity →	+0.112	+0.121	<.001	<.001	3	17
STAD	Immunoglobulin production →	+0.083	+0.441	<.001	<.001	3	16
STAD	Regulation of B cell proliferation →	+0.086	+0.526	<.001	<.001	3	16
KIRC	Regulation of cell-cell adhesion mediated by integrin →	+0.137	+0.100	<.001	<.001	3	16
SKCM	Alpha-beta T cell activation →	+0.076	+0.330	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,817 associations by consensus.

B cell activation by IGHD1-7 expression — PRAD

Explore this box plot interactively →