IGHD1-7

Across TCGA pan-cancer cohorts, IGHD1-7 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGHD1-7 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGHD1-7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHD1-7 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

COAD, MESO, and LUAD are the cancer types where IGHD1-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.126	0.677	<.001	102	view →
MESO	OS	Tertile	III,IV	0.077	0.580	<.001	54	view →
LUAD	OS	Tertile	All	0.807	0.309	.005	24	view →
KIRC	OS	Tertile	All	0.364	0.638	.004	24	view →
LGG	DFS	Tertile	All	0.249	0.738	.023	18	view →
PCPG	OS	Tertile	All	0.904	1.000	.005	18	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
SKCM	DFS	Tertile	All	0.852	0.725	.031	9	view →
LUSC	OS	Tertile	II,III,IV	0.240	0.434	.030	9	view →
OV	DFS	Tertile	All	0.298	0.153	.042	6	view →
LAML	DFS	Tertile	All	0.295	0.549	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGHD1-7–COAD (DFS)

Open the COAD breakdown →