IGHD1-20

Across TCGA patient cohorts, IGHD1-20 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,695 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD1-20-associated proteins across cancer lineages are THEMIS2, CD48, and ACAP1. Each is linked with IGHD1-20 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHD1-20-to-partner and partner-to-IGHD1-20 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHD1-20 versus THEMIS2 in CCRCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD1-20→partner) and Y-score (partner→IGHD1-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	THEMIS2 →	+0.374	+0.993	<.001	.004	3	6
BRCA	CD48 →	+0.641	+0.563	.003	.002	3	6
BRCA	ACAP1 →	+0.480	+0.906	.003	<.001	3	6
CCRCC	DOCK2 →	+0.487	+1.202	<.001	<.001	3	6
CCRCC	SAMSN1 →	+0.517	+0.763	<.001	<.001	3	5
BRCA	SEPTIN1 →	+0.743	+0.769	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,695 associations by consensus.

IGHD1-20 vs THEMIS2 — CCRCC

Explore this scatter interactively →