IGHD1-20

Across TCGA pan-cancer cohorts, IGHD1-20 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGHD1-20 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHD1-20 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHD1-20 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

LUAD, OV, and KIRP are the cancer types where IGHD1-20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.638	0.275	.004	81	view →
OV	DFS	Tertile	All	0.695	0.368	.004	66	view →
KIRP	DFS	Tertile	All	0.176	0.829	<.001	54	view →
LAML	DFS	Tertile	All	0.292	0.569	.004	36	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →
HNSC	DFS	Tertile	III,IV	0.866	0.314	.019	33	view →
KIRC	DFS	Tertile	All	0.367	0.639	.018	30	view →
DLBC	DFS	Tertile	All	0.391	0.906	.005	27	view →
PCPG	OS	Tertile	All	0.901	0.992	.003	25	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
PAAD	OS	Tertile	II,III,IV	0.622	0.357	.020	18	view →
LUSC	OS	Tertile	III,IV	0.204	0.652	.035	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGHD1-20–LUAD (OS)

Open the LUAD breakdown →