Across TCGA pan-cancer cohorts, IGHA1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated IGHA1 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IGHA1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHA1 expression acts as an unfavorable survival marker.
ACC, DLBC, and SARC are the cancer types where IGHA1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.