Across TCGA pan-cancer cohorts, IGHA1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHA1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where IGHA1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHA1 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.
COAD, LIHC, and KIRC are the cancer types where IGHA1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHA1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.