Across TCGA pan-cancer cohorts, IGHA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGHA1 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where IGHA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.776	0.982	.007	38	view →
LUAD	OS	Median	All	0.923	1.000	.002	30	view →
PDAC	OS	Tertile	III,IV	0.977	0.427	.017	9	view →
HNSC	OS	Median	All	0.954	1.000	.010	6	view →
CCRCC	DFS	Tertile	II,III,IV	0.260	0.859	.035	6	view →
GBM	DFS	Quartile	All	0.571	0.232	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: IGHA1 tumor-vs-normal RNA expression · all IGHA1 data types