IGFLR1

Across TCGA patient cohorts, IGFLR1 mutation is significantly associated with the RNA expression of many other genes, with 312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFLR1-associated genes across cancer lineages are RNA5SP419, RNA5SP423, and MMP21. Each is linked with IGFLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFLR1-to-partner and partner-to-IGFLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by IGFLR1-low versus IGFLR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFLR1→partner) and Y-score (partner→IGFLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP419 →	+0.837	+2.813	<.001	.003	3	2
UCEC	RNA5SP423 →	+0.861	+2.980	<.001	.001	3	2
UCEC	MMP21 →	+0.220	+3.343	<.001	.005	3	1
UCEC	GPR61 →	+0.204	+3.343	.003	.005	3	1
UCEC	FCRL3 →	+0.484	+3.332	.002	.005	3	1
UCEC	SLAMF6 →	+0.947	+3.332	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 312 associations by consensus.

RNA5SP419 by IGFLR1 expression — UCEC

Explore this box plot interactively →