Across TCGA patient cohorts, IGFL1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFL1-associated genes across cancer lineages are ERK2, Ku80, and MEK1. Each is linked with IGFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFL1-to-partner and partner-to-IGFL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFL1→partner) and Y-score (partner→IGFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.217	+3.169	.040	.020	3	1
UCEC	Ku80 →	+0.324	+3.183	.012	.010	3	1
UCEC	MEK1 →	+0.403	+3.000	.044	.036	3	1
UCEC	Src_pY416 →	-0.303	-3.156	.022	.020	3	1
UCEC	VHL →	-1.222	-3.169	.001	.019	3	1
UCEC	PCNA →	+0.258	+3.169	.030	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

IGFL1 survival (RNA) · tumor vs normal (RNA) · all IGFL1 data types