IGFBP7

Across TCGA patient cohorts, IGFBP7 protein abundance is significantly associated with the RNA expression of many other genes, with 16,624 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGFBP7-associated genes across cancer lineages are MSRB3, HIC1, and MEIS3. Each is linked with IGFBP7 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGFBP7-to-partner and partner-to-IGFBP7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP7 versus MSRB3 in BRCA, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP7→partner) and Y-score (partner→IGFBP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSRB3 →	+1.227	+0.589	<.001	<.001	3	10
OV	HIC1 →	+0.651	+0.444	<.001	.002	3	10
UCEC	MEIS3 →	+1.065	+0.638	<.001	<.001	3	9
OV	AEBP1 →	+1.663	+0.457	<.001	.001	3	9
OV	ACTA2 →	+1.975	+0.581	<.001	.002	3	9
OV	LAMA4 →	+0.949	+0.561	.003	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,624 associations by consensus.

IGFBP7 vs MSRB3 — BRCA

Explore this scatter interactively →