IGFBP7-AS1

Across TCGA pan-cancer cohorts, IGFBP7-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated IGFBP7-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IGFBP7-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGFBP7-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LAML show a favorable association.

ACC, UVM, and UCEC are the cancer types where IGFBP7-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.203	0.678	<.001	72	view →
UVM	DFS	Quartile	All	0.428	0.959	<.001	57	view →
UCEC	DFS	Median	III,IV	0.867	0.716	.001	44	view →
MESO	OS	Median	All	0.282	0.489	.001	42	view →
LAML	DFS	Tertile	All	0.598	0.274	.001	40	view →
LGG	DFS	Median	All	0.784	0.876	<.001	36	view →
LUAD	OS	Median	II,III,IV	0.636	0.463	.001	31	view →
THCA	OS	Tertile	II,III,IV	0.940	1.000	.005	30	view →
CHOL	DFS	Quartile	All	0.889	0.121	<.001	21	view →
READ	OS	Tertile	All	0.839	1.000	.011	21	view →
GBM	OS	Quartile	All	0.300	0.594	.006	17	view →
OV	OS	Quartile	II,III,IV	0.764	0.659	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

IGFBP7-AS1–ACC (DFS)

Open the ACC breakdown →