IGFBP7-AS1

Across TCGA pan-cancer cohorts, IGFBP7-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IGFBP7-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IGFBP7-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGFBP7-AS1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and KIRC are the cancer types where IGFBP7-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGFBP7-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−0.750	<.001	11	view →
BLCA	All	All	−0.276	.001	8	view →
KIRC	Male	II,III,IV	−0.184	<.001	8	view →
KIRP	All	All	−0.271	<.001	7	view →
UCEC	All	All	−0.695	<.001	6	view →
COAD	All	All	+0.671	<.001	5	view →
LUAD	All	III,IV	−0.205	.002	5	view →
THCA	Female	II,III,IV	−0.200	.008	3	view →
HNSC	All	III,IV	+0.090	.007	3	view →
LUSC	Female	All	−0.167	.005	2	view →
LIHC	Female	All	+0.121	.023	2	view →
PRAD	All	All	−0.121	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IGFBP7-AS1–KICH

Open the KICH breakdown →