IGFBP5

Across TCGA pan-cancer cohorts, IGFBP5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGFBP5 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGFBP5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGFBP5 expression acts as an unfavorable survival marker.

LUAD, COAD, and GBM are the cancer types where IGFBP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.782	1.000	.003	41	view →
COAD	DFS	Median	All	0.888	1.000	.023	12	view →
GBM	DFS	Tertile	All	0.279	0.506	.011	12	view →
CCRCC	DFS	Quartile	II,III,IV	0.066	0.904	.024	11	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
HNSC	OS	Quartile	All	0.621	0.785	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGFBP5–LUAD (OS)

Open the LUAD breakdown →