IGFBP5

Across TCGA pan-cancer cohorts, IGFBP5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of IGFBP5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where IGFBP5 RNA is repressed in tumor relative to normal tissue. In most cancer types IGFBP5 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where IGFBP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGFBP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−4.200	<.001	9	view →
KIRC	Male	III,IV	−1.340	<.001	8	view →
KICH	All	All	−1.141	<.001	8	view →
UCEC	All	All	−2.724	<.001	6	view →
BLCA	Male	All	−2.452	<.001	6	view →
LUSC	All	All	+0.902	<.001	4	view →
LUAD	All	II,III,IV	+0.881	.003	4	view →
BRCA	Female	All	−0.462	.007	4	view →
CHOL	All	All	+1.980	.009	2	view →
HNSC	Male	All	−0.998	.019	2	view →
ESCA	Female	All	−2.143	.047	1	view →
STAD	Male	IV	−0.570	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

IGFBP5–KIRP

Open the KIRP breakdown →