IGFBP5

Across TCGA patient cohorts, IGFBP5 protein abundance is significantly associated with the RNA expression of many other genes, with 12,594 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGFBP5-associated genes across cancer lineages are DIRC3-AS1, MYL9, and NALCN. Each is linked with IGFBP5 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGFBP5-to-partner and partner-to-IGFBP5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP5 versus DIRC3-AS1 in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP5→partner) and Y-score (partner→IGFBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DIRC3-AS1 →	+0.721	+0.809	<.001	<.001	3	7
COAD	MYL9 →	+1.693	+0.790	<.001	<.001	3	6
PDAC	NALCN →	+0.488	+0.566	<.001	<.001	3	6
OV	LOXL1 →	+1.035	+0.532	<.001	<.001	3	6
OV	CNN1 →	+1.325	+0.682	<.001	<.001	3	6
GBM	IGFBP3 →	+1.567	+0.579	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,594 associations by consensus.

IGFBP5 vs DIRC3-AS1 — LSCC

Explore this scatter interactively →