IGFBP5

Across TCGA patient cohorts, IGFBP5 mutation is significantly associated with the RNA expression of many other genes, with 1,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP5-associated genes across cancer lineages are OR6M3P, RNU2-47P, and RN7SL638P. Each is linked with IGFBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP5-to-partner and partner-to-IGFBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6M3P grouped by IGFBP5-low versus IGFBP5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP5→partner) and Y-score (partner→IGFBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR6M3P →	+0.049	+6.810	<.001	<.001	3	2
UCEC	RNU2-47P →	+0.082	+4.060	<.001	.006	3	2
UCEC	RN7SL638P →	+0.129	+2.511	.005	.003	3	2
UCEC	CELF1 →	+0.427	+2.609	.004	.006	3	1
UCEC	COX15 →	+0.533	+2.592	<.001	.006	3	1
UCEC	NPAT →	+0.535	+2.708	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,102 associations by consensus.

OR6M3P by IGFBP5 expression — SKCM

Explore this box plot interactively →