IGFBP5

Across TCGA cell cohorts, IGFBP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,072 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IGFBP5-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Golgi vesicle transport, and Negative regulation of myoblast fusion. Each is linked with IGFBP5 in more than 14 cancer types. Because this analysis shows association rather than direction, both IGFBP5-to-partner and partner-to-IGFBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by IGFBP5-low versus IGFBP5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP5→partner) and Y-score (partner→IGFBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.111	+2.335	.002	.005	2	15
LUNG_SCLC	Golgi vesicle transport →	+0.056	+3.186	.001	.004	3	13
OVARY	Negative regulation of myoblast fusion →	+0.114	+2.158	<.001	<.001	3	12
LIVER	Regulation of intracellular transport →	+0.069	+3.237	<.001	.004	3	12
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.093	+1.765	<.001	<.001	3	12
STOMACH	Regulation of proteasomal protein catabolic process →	+0.074	+3.091	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,072 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by IGFBP5 expression — STOMACH

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