IGFBP5

Across TCGA cell cohorts, IGFBP5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGFBP5-associated genes across cancer lineages are ADAM7 and TKTL2. Each is linked with IGFBP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP5-to-partner and partner-to-IGFBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by IGFBP5-low versus IGFBP5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP5→partner) and Y-score (partner→IGFBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TKTL2 →	+0.052	+3.187	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ADAM7 by IGFBP5 expression — LARGE_INTESTINE

Explore this box plot interactively →