IGFBP3

Across TCGA patient cohorts, IGFBP3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,475 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IGFBP3-associated proteins across cancer lineages are IGFBP3_S201, RAI14, and TUBB6. Each is linked with IGFBP3 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGFBP3-to-partner and partner-to-IGFBP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP3 versus IGFBP3_S201 in GBM, with a Pearson correlation of 0.79.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP3→partner) and Y-score (partner→IGFBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IGFBP3_S201 →	+1.491	+1.977	<.001	<.001	3	8
UCEC	RAI14 →	+0.377	+1.031	<.001	<.001	3	7
PDAC	TUBB6 →	+0.542	+1.039	<.001	<.001	3	7
PDAC	COMP →	+1.230	+1.152	<.001	<.001	3	7
BRCA	TIMP2 →	+0.613	+0.714	<.001	<.001	3	7
OV	MMP2 →	+0.798	+1.148	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,475 associations by consensus.

IGFBP3 vs IGFBP3_S201 — GBM

Explore this scatter interactively →