IGFBP3

Across TCGA pan-cancer cohorts, IGFBP3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGFBP3 data layer compared with 6 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IGFBP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGFBP3 expression acts as an unfavorable survival marker, although some lineages such as DLBC and UCS show a favorable association.

KIRP, MESO, and KICH are the cancer types where IGFBP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.340	0.717	<.001	135	view →
MESO	OS	Median	All	0.269	0.499	<.001	108	view →
KICH	DFS	Median	All	0.687	0.974	.001	62	view →
LGG	DFS	Median	All	0.328	0.501	<.001	54	view →
DLBC	DFS	Tertile	All	1.000	0.652	.003	36	view →
LIHC	OS	Median	All	0.710	0.837	<.001	34	view →
ACC	OS	Tertile	All	0.278	0.838	.002	28	view →
THYM	OS	Tertile	All	0.749	1.000	.006	26	view →
UCS	OS	Tertile	IV	0.883	0.296	.024	24	view →
THCA	OS	Median	II,III,IV	0.812	1.000	.007	22	view →
BLCA	OS	Tertile	III,IV	0.440	0.736	.008	18	view →
PAAD	OS	Tertile	All	0.393	0.659	.021	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGFBP3–KIRP (OS)

Open the KIRP breakdown →