IGFBP3

Across TCGA patient cohorts, IGFBP3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,364 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGFBP3-associated genes across cancer lineages are FN1, CALU, and LOXL2. Each is linked with IGFBP3 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGFBP3-to-partner and partner-to-IGFBP3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP3 versus FN1 in COAD, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP3→partner) and Y-score (partner→IGFBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FN1 →	+1.717	+0.684	<.001	<.001	3	7
BRCA	CALU →	+0.741	+0.490	<.001	<.001	3	7
OV	LOXL2 →	+1.056	+0.642	.002	.008	3	7
GBM	TMEM45A →	+0.905	+0.692	<.001	.004	3	7
OV	CALHM5 →	+0.763	+0.797	.001	.003	3	7
GBM	TIMP1 →	+1.249	+0.640	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,364 associations by consensus.

IGFBP3 vs FN1 — COAD

Explore this scatter interactively →