IGFBP3

Across TCGA patient cohorts, IGFBP3 mutation is significantly associated with the RNA expression of many other genes, with 1,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP3-associated genes across cancer lineages are MIR3928, RNA5SP436, and MIR4445. Each is linked with IGFBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP3-to-partner and partner-to-IGFBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3928 grouped by IGFBP3-low versus IGFBP3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP3→partner) and Y-score (partner→IGFBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR3928 →	+0.680	+5.285	<.001	.001	3	2
UCEC	RNA5SP436 →	+0.482	+3.200	<.001	.006	3	2
UCEC	MIR4445 →	+0.248	+5.019	<.001	.001	3	2
SKCM	OR11H2 →	+0.036	+4.513	<.001	.009	3	2
SKCM	LINC02122 →	+0.080	+5.080	<.001	.004	3	1
UCEC	PES1 →	+0.604	+3.584	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,084 associations by consensus.

MIR3928 by IGFBP3 expression — LUAD

Explore this box plot interactively →